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Case report: add-on treatment with odevixibat in a new subtype of progressive familial intrahepatic cholestasis broadens the therapeutic horizon of genetic cholestasis

Analysis of candidate cis-regulatory elements (cCREs) has shown that some diabetes-associated variants reduce chromatin accessibility at binding sites for transcription factors such as HNF1A and HNF4A, thereby impairing maintenance of a functional phenotype (Wang et al., 2023)

L.PrasainJ.KingJ.ArabshahiA.BarnesS.WeaverC

This constant requirement for NAD + synthesis can be met by using 2 independent routes

The rationale is that AOD 9604 preferentially targets adipose tissue, which might help shift the composition of weight loss more toward fat and away from lean mass

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