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Importantly, Hinton and colleagues showed that human IgG2 variants harboring Fc fragments with amino acid substitutions that increase their binding affinity towards human FcRn at specifically pH 6.0, but not pH 7.4, had prolonged plasma half-lives in non-human primates (NHPs) [104]

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Massey PA, Myers M, McClary K, Brown J, Barton RS, Solitro GF: Biomechanical analysis of patellar tendon repair with knotless suture anchor tape versus transosseous suture