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Side effects, when they occur, tend to be mild and dose related, such as injection site irritation or temporary water retention

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Stanford's classification further categorizes dissections into those involving the ascending aorta (Type A) or not (Type B) ( Oxidative stress refers to an imbalance between the production of reactive oxygen species (ROS) and endogenous antioxidant defense mechanisms

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This may explain why side effects are relatively rare compared to pharmaceutical approaches that introduce foreign signaling molecules