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In particular, increased mitochondrial oxidative stress in fibroblast-derived induced pluripotent stem cells, differentiated into human nigral DA neurons, triggers a DA-dependent toxic cascade, leading to oxidized DA accumulation and reduction in glucocerebrosidase enzymatic activity, lysosomal dysfunctions, and -syn accumulation [49]

Copper: role of the endogenous and exogenous metal on the development and control of inflammatory processes

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Pascoe et al

Meanwhile, the intrinsic GPx-like activity of ACPP constantly consumes GSH with the assistance of H 2 O 2 and protection of generated ROS to break the antioxidant defense effect of the tumor and further inhibit GPX4 activity, ultimately promoting lipid peroxidation (LPO) accumulation and enhancing the ferroptosis effect

Furthermore, the secretory level of HD5 positively correlates with the relative abundance of Bifidobacterium throughout the infancy, especially at the weaning