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10.1016/j.molmed.2019.10.007 22 CaiC.WuF.HeJ.ZhangY.ShiN.PengX.et al (2022)

First-line inavolisib/placebo + palbociclib + fulvestrant (Inavo/Pbo+Palbo+Fulv) in patients (pts) with PIK3CA-mutated, hormone receptor-positive, HER2negative locally advanced/metastatic breast cancer who relapsed during/within 12 months (mo) of adjuvant endocrine therapy completion: INAVO120 Phase III randomized trial additional analyses

These reactive molecules have a signaling function, modifying the Keap1 protein, which leads to Nrf2 activation (124)

Unfortunately, however, results from other studies have been conflicting

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