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P.AlbieroM.MenegazzoL.BoscaroE.PagninE.IoriE.et al (2010)

"Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents"

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In addition, a relative insulin deficiency stimulates gluconeogenesis in the liver and lipolysis in the adipose tissue, resulting in the release of glucose and free fatty acids, and, thereby further increasing the levels of circulating energy sources

Progression to end-stage kidney disease ESKD is due to interstitial fibrosis, tubular atrophy, collapsing glomeruli, and mesangial proliferation [9]

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