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Additionally, NRC-03 and NRC-07, two AMPs from the pleurocidins AMP family, exhibited equal killing effect at a concentration of 50M on normal MCF7 cells and on paclitaxel-resistant breast cancer cell line MCF7-TX400 that possess 2.6 times of P-gp expression more than the normal MCF7 cells, achieving about 60% of cell killing rate

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Recent experiments indicated a role for GPx4 in tumor angiogenesis by suppressing lipid peroxidation derived from 12/15-lipoxygenase activity or cycloxygenase-2 possibly via modulation of ROS sensitive tyrosine kinase signaling pathways (Heirman et al., 2006

Glutamine-addicted ccRCC tumors deprive the tumor microenvironment of glutamine

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Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, Kritchevsky SB, Fellin R, Harris TB (2004) Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the health, aging, and body composition study