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As the field advances toward personalized medicine, single-cell transcriptomics has revealed interindividual variability in neuronal glycolysis-oxidative phosphorylation balance (e.g., differential GLUT1/4 expression affecting substrate selection in APP/PS1 mice), offering new strategies for targeting AMPK-mediated astrocyte glycogenolysis to optimize neuronal energy supply (Wu et al., 2024)

Bermea, K

Mounjaro slows gastric emptying, which means oral medications like the pill spend more time in your stomach than they do in your intestines

personal fees from Roche and Edomond Pharma

Negi JS, Chattopadhyay P, Sharma AK, Ram V

Biochem J 300 : 271276 Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient