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Initially excess copper is stored in cytosolic metallothionein

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Cognitive reserve is made from several components: (1) the brain reserve (which reflects the anatomical individual differences quantified by the number of neurons and synapses), (2) the brain maintenance supported by all homeostatic pathways from cellular to organ level), (3) the brain resilience (the ability to withstand stress without mounting the pathology) and (4) the brain compensation directly linked to the regenerative capacity of the nervous tissue

To these resuspended cultures, meropenem (MEM) at 0.5 g/mL, ampicillin (AMP) at 3.5 g/mL, and cephazolin (CAZ) at 1.5 g/mL were added, along with 10 mM hydrogen peroxide (H 2 O 2 ) as the positive control