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2019;6(12):e821e830

Br Med J (Clin Res Ed) (1988) 296:7413.10.1136/bmj.296.6624.741 7 BulunSEPriceTMAitkenJMahendrooMSSimpsonER

Titrate: Increase gradually every few weeks as tolerated

half-life of 6-7 hrs Side Effects: Bradycardia, hypotension, reversible depression, disorder of respiratory drive For more information on beta-blocker CNS side effects (see Propranolol)