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In contrast, CuN x -CNS exhibits robust absorption in the second near-infrared (NIR-II) biowindow, facilitating photothermal treatment in deep tissues and NIR-II-responsive enhancement of ROS production

A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection