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When early tangle-bearing neurons undergo ferroptosis, the released free iron triggers neighboring microglia to initiate ferritin synthesis, aiming to lower extracellular iron concentration through intracellular sequestration (138, 139)

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Congruently, expression of glutamine synthase (GS), an effector molecule of the -catenin pathway which is expressed by peri-central hepatocytes, increased significantly by IF in pIVCL mice livers compared to sham (fold change 1.85, p value 30%, and veterans for whom LSM was obtained after HCC diagnosis were excluded

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