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Bromelain has been extensively studied for its implication in cell death, indeed it can intervene in the expression of Bcl-2, a type of protein with an anti-apoptotic effect but can also positively regulates the expression of apoptotic genes, such as Bax, Apaf-1, and caspases-9 and -3 ( In vitro studies have shown that bromelain can induce apoptosis

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The demand for effective, non-invasive treatments that promote vitality and longevity is driving the growth of this therapy

The intestinal flora of patients with GHPA affects the growth and the expression of PD-L1 of tumor