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Gclc mRNA and GSH levels were reduced in mice with Gclc specifically knocked out in the tumour (Fig

R package version 2.0.3 edn Beal MA, Audebert M, Barton-Maclaren T et al (2023) Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

These mechanisms supply energy and nutrients for their own growth and reproduction while producing many metabolites that infiltrate the host system (82, 83)

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No skin changes at 12 weeks on a high-bioavailability route individual melanin biology varies

Because APAP-induced liver injury and recovery is regulated by an intricate system of intra- and extracellular molecular signaling, we here aim to quantify the importance of specific modules in determining the outcome after an APAP insult and of potential targets for therapies that mitigate adversity