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Type 1 TI (TI-1) antigens interact with B cells through both membrane immunoglobulin receptors and innate immune receptors (Fig

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The integrase strand transfer inhibitor dolutegravir (DTG) is a frontline antiretroviral drug that is effective in viral suppression of HIV but was previously reported to be associated with a slight increase in the risk for neural tube defects in one study, although this has not been replicated in other cohorts

PMID 23235645