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Box 1 Despite the limited value of measuring blood cytokine levels in understanding pathophysiology and neuroinflammation, blood cytokine levels are used as a dependent variable in many ME/CFS studies, probably due to ease of collection

Pharmacokinetic/pharmacodynamic modeling is used to relate plasma ipamorelin concentrations to GH release profiles across dosing intervals

The original studies of acetylcysteine suggested that all patients who received early treatment would do well

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[2],[3],[5],[9],[21] Thus, the medical exposure was the most common source of argyria

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