glutathione function in drug metabolism Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Detoxification and Bioactivation Glutathione: pharmacological aspects and implications

10.1186/2050-6511-13-8 BMC Pharmacol

Ferroptosis: mechanisms and implications for cancer development and therapy response

While glutathione supports cellular antioxidant defense theoretically, no published randomized trials confirm benefit in this specific population

112 Chronic inflammation in the TME, which is mediated by cytokines such as IL-6, IL-8, and TNF-, can drive epigenetic and transcriptional reprogramming via the NF-B, JAK/STAT, and COX-2 pathways

The review was conducted under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, where applicable, to ensure transparency and reproducibility

By restoring gut integrity and reducing GI inflammation, BPC-157 effectively shuts off the tap of these pro-inflammatory signals at their source