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Esomeprazole is protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide

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Cochrane Database Syst Rev (2015) 2):Cd010009

Vitamin B12 deficiency is more common in people who follow a plant based or vegetarian diet, in people who do not produce intrinsic factor, or those where the intrinsic factor is not able to mix with the food such as after bariatric surgery