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Consistent with this, activated microglia form clusters around blood vessels in hypertensive eyes (110) and dendritic and synaptic architecture in rodent glaucoma can be protected not only by inhibiting the C1q protein or deleting its gene, but also by blocking pressure-induced immigration of macrophages/monocytes (60, 81)

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Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

W-C L, Kopetz S , Wistuba II, Zhang J

Although astrocyte reactivity serves as an initial defensive mechanism, excessive or prolonged reactivity has been implicated in the progression of neurodegenerative diseases

doi: 10.1016/s0891-5849(02)01084-5