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Breastfeeding Monitoring required GX 600 INJECTION is not recommended for use in breastfeeding women unless it is clearly necessary

Depending on tolerance, this dosage may be increased by an additional 25 mg every 3 to 4 days, up to a maximum of 200 mg per day

Interestingly, the demethylated metabolite of tramadol, desmetramadol is a weaker inhibitor of hNET (IC 50 = 6 M) relative to tramadol (IC 50 = 2 M) 56

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