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A direct administration of CRISPR-Cas9 therapeutic requires a safe and precise delivery of its systems in vivo

Analysis of the docking conformation (Fig

It passes through the blood-brain barrier with ease and is welcomed by the brain cells (neurons, microglia, and astrocytes)

Furthermore, PPE is capable of modulating several critical molecular pathways, including mitogen-activated protein kinases, nuclear factor-kappa B (NF-B), cysteine-aspartic acid-specific proteases, and peroxisome proliferator-activated receptors, thus providing theoretical support for its use in the treatment of a variety of diseases (Ganeshkumar et al., 2013