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arr1 adopts an active conformation 12 , characterized by C-tail displacement and inter-domain rotation, and binds to the aromatic surface of SH3 containing residues from the RT loop, nSrc loop, and the 3 10 helix (Fig

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Accordingly, further research is warranted to determine the optimal utilization of ARNi in the context of CIC and to establish its safety and efficacy in this specific population