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On the contrary, NRF2 activators targeting KEAP1 thiols are recognized for their preventive potential for oxidative stress-related pathology such as Parkinsons disease, but have not proven effective for chronic patients largely due to their electrophilic high off-target nature [93]

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The assessment of results was made at 24 and 96 hours after peptide administration and included changes in the kidneys on a scale from 0 to 3, where: 0 - healthy kidney, 1 - mild hydronephrosis, 2 - moderate hydronephrosis, visible dilation of the renal pelvis, few changes on the kidney surface, 3 - severe hydronephrosis, dilation of the renal pelvis, thinning of the renal parenchyma, and a significant number of changes on the kidney surface

Evidence caveat: The combination approach is based on clinical observation and mechanistic reasoning, not controlled trials

Our model accurately predicts patient death or recovery depending on size of APAP overdose and time of treatment