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10.1016/j.rvsc.2022.02.015 35 Centers for Disease Control and Prevention (CDC) (2015b)

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Determining the optimal duration of pharmacological interventions, potential long-term side effects, and the impact of HU management on cardiovascular outcomes requires further investigation

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In neurological diseases, in response to pathological changes in the nervous system, microglia undergo morphological changes, and these cells secrete a different group of inflammatory mediators, including chemicals, cytokines, and cytotoxic molecules

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Oxidative stress is a key factor in inducing HSC activation

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