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Its safety and efficacy in humans have not been established

10.1016/j.mehy.2011.03.030 Med

The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Kalfalah F, Sobek S, Bornholz B, et al

Another rare side effect

Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins