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Following single oral doses R , S -lipoic acid (racemic mixture), peak plasma concentrations of R -lipoic acid were found to be 40%-50% higher than S -lipoic acid, suggesting a differential absorption in favor of the R -enantiomer (6, 8, 11)

Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes

Yakar et al., 2004)

Another limitation of many of the cited studies was that although the majority of the authors gave justification for research (hypothesis specifically was not always outlined), they did not appear to critically evaluate their own methodologies