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Some of those include metformin which is used in type 2 diabetes, heartburn medications that alter the production of stomach acid such as PPIs or H2 blockers, and oral contraceptives

The clinical reality is much narrower than the marketing

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Front Endocrinol (Lausanne) 8:315

Those who dont regularly consume animal products rich in vitamin B12 may want to consider adding fortified foods to their diet or taking a supplement to ensure that their nutritional needs are met

Keep technique consistent: Dont change diluent volume or handling style halfway through a study unless the protocol itself changes