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Patients with KRAS G12D mutations have poor survival outcomes, and this mutation is a marker of poor prognosis in Chinese patients [11]

The lack of Sil1 impairs protein folding, leads to UPR and indirectly alters mitochondrial morphology 23,26,27,28,36,37

doi: 10.1016/j.jconrel.2015.12.016 147 MushtaqAMohd WaniSMalikARGullARamniwasSAhmad NayikGet al

8.1.2 Oral and intraperitoneal exposure In rat models liver microsomes decreased content of cytochrome P-450 was observed for single oral dose of 1000 mg/kg body weight