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This misalignment causes chronic insomnia or excessive sleepiness12

All authors approved the final version of the manuscript

183 Another approach has been based on the observation that emphysema patients showed a marked reduction in the levels of hyaluronic acid, 184 and that therapy with hyaluronic acid protected elastase-induced emphysema in mice

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Driving and inhibiting ferroptotic mechanisms Ferroptosis, a type of non-apoptotic cell death, is characterized by three main processes that affect the sensitivity of cells to ferroptosis: (1) an increase in the content of free iron that generates ROS through the Fenton reaction, (2) a depletion of the antioxidant glutathione (GSH) and a loss of glutathione peroxidase 4 (GPX4) activity, and (3) an accumulation of lipid peroxidation products and a disruption of cell membranes [12]