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As no effective therapies to retard or reverse disc degeneration have yet been devised, there is huge interest in potential regenerative treatments for human patients

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The phosphorylation status of mTORC1 substrates including S6 S240/S244 and 4E-BP1 T37/S46 were assessed in the brain along with autophagy receptor p62 (sequestosome 1, SQSTM1) and the autophagosome marker LC3A/B

ROS/PI3K/Akt and Wnt/-catenin signalings activate HIF-1-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

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