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Mechanistically, microglia with elevated G6PD activity produce excess NADPH, which provides abundant substrate for overactivated NOX2

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Furthermore, CSCs exhibit critical features of embryonic stem cells (ESCs) in terms of transcriptional factor expression (SOX2, OCT4, NANOG, MYC, KLF4, SALL4, and FOXM1) and signaling pathways (like Wnt/-catenin, Hedgehog, Hippo, Notch, and TGF-) [99,100,101]

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10.3389/fphar.2021.653641 13

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