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Immune thrombocytopenia: recent advances in pathogenesis and treatments

Literature estimates for K m are reported to be 30300 times larger 41,42 than the CZX concentration considered (1 uM) so we were able to adopt linear kinetics for CYP2E1 activity (enzyme velocity = [S], where [S] = CZX concentration and = V max /K m ) instead of the full nonlinear Michaelis-Menten form

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Hemil H., Chalker E

Full S6K1 activation also requires its phosphorylation by a second factor, PDK1 (Phosphoinositide-dependent kinase-1), which takes place at distinct residues (Pullen et al., 1998)

[DOI] [PubMed] [Google Scholar] 91.Buchard A, Eefsen M, Semb S, Andersen SE, Morling N, et al

Both promote tissue repair, but they work through completely different mechanisms which is why many researchers study them together