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Atovaquone used alone can cause drug resistance but evidence that clindamycin and atovaquone with azithromycin can effectively treat Babesia has previously been reported in both animals [171], and humans [172], although there is now greater recognition of resistance to standard Babesia regimens [153,163], especially in immunocompromised patients with babesiosis when 6 weeks of therapy or longer may be necessary [172]

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The authors demonstrated that the application of 300 mM dopamine for 24 h stimulated apoptosis due to ROS formation