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Additionally, it was found that increased PGE 2 production resulting from topical application of a mycotoxin (alternariol-AOH) to mouse skin leads to activation of the EP2 receptor, which increases cAMP levels promoting phosphorylation of the cAMP response element-binding protein (CREB) transcription factor, which regulates the transcription of genes responsible for the proliferation of primary mouse keratinocytes (PMK) [166]

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Since these 4 potential new supplies had no pricing information and are not currently included as direct PE inputs for any HCPCS codes, we did not add them to our direct PE database for the CY 2025 proposed rule due to lack of available information