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Disclosures: Shuang Liang: Nothing to Disclose, Chuanli Zhou: Nothing to Disclose, Zhenyu Zhong: Nothing to Disclose 2627 SERUM IGG REFLECTS HISTOLOGICAL ACTIVITY IN CHILDREN WITH AUTOIMMUNE HEPATITIS Or Steg Saban 1 Shannon Vandriel 2 Desiree Vaz 1 Celine Bourdon 1 Amrita Mundh 1 Vicky Ng 2 Simon Ling 1 Robert Bandsma 1 Iram Siddiqui 1 Binita Kamath 1 , 1 The hospital for sick children, 2 Hospital for Sick Children Background: Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease and evaluating disease activity can be a challenge

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High doses of oral Vitamin C may lead to gastrointestinal discomfort, such as bloating, diarrhea, or kidney stones in vulnerable individuals

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This mechanism includes: Transporter Hijacking : Ephedrine is a substrate for the membrane-bound norepinephrine transporter (NET) (Solanki et al, 2014)

Concentrated formula ensures optimal dosage for maximum effectiveness