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From the excitotoxic point of view, overexpression of TNF favors the activity of excitatory synapses, inhibits uptake of glutamate by astrocytes and increases release of glutamate from microglia, which all leads to overload of extracellular space with this mediator and results in self-perpetuating excitotoxic insult (Olmos and Llad, 2014)

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the composition comprises a cannabinoid selected from the group consisting of cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Cannabichromene (CBC), Cannabicyclol (CBL), Cannabivarin (CBV), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV), Cannabigerovarin (CBGV), Cannabigerol Monomethyl Ether (CBGM), Tetrahydrocannabinol (THC), cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), Cannabichromenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocannabivari the antioxidant is selected from the group consisting of: L-ergothioneine, butylated hydroxytolune (BHT), butylated hydroxy anisole (BHA), tert-Butylhydroquinone (TBHQ), pyrogallol, propylgallate, N,N-Di-sec-butyl-p- phenylenediamine, coenzyme Q10, astaxanthin, ellagic acid, picrocrocin, lycopene, lutein/zeaxanthin, lutein, zeaxanthin, quercetin, vitamin C, IP-6, beta-carotene, epicatechin, ECGC-epigallocatechin gallate, safranal, proanthocyanidins, resveratrol, vitamin E, melatonin, and mitoQ

Within these studies, increased NET formation was also specifically associated with certain complications of COVID-19 infections, including vascular occlusion and pneumocyte damage, allowing NETs to be labelled as multi-purposed in the immune response against SARS-CoV-2 and other viruses [26, 28,29,30,31]