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Craig: No, literally, like as a physician, it's such an honor to be here and to talk to you because every day my patients come to me and said, "I heard this on the Huberman Lab podcast

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Loren Pickart, it's found in blood, saliva, and urine and its plasma levels drop sharply with age: Age 20 : ~200 ng/mL Age 60 : ~80 ng/mL Age 80 : ~50 ng/mL That 75% decline correlates with decreased wound healing capacity, accelerated skin aging, and diminished systemic repair signaling

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It represents the minimal bioactive fragment commonly utilised in research settings to investigate melanocortin-associated signalling independently of the full-length peptide