Cellular energy utilisation models
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2005: CD004655
Research suggests AOD-9604 may preserve existing muscle tissue during caloric restriction (a muscle-sparing effect), but this differs from actively building new muscle
The researchers proposed that the compounds effects on muscle function operate through boosting NAD+ levels by inhibiting NNMTs consumption of nicotinamide, more substrate is available for NAD+ synthesis via the salvage pathway, supporting mitochondrial function and energy metabolism in aged skeletal muscle
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