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Genomic studies have uncovered several genetic markers underlying the pathology of pulmonary arterial hypertension and cardiomyopathies, which have been used to design polygenic risk score with prediction accuracies as high as 40% (46, 47, 51)

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F.2007Cytochrome p450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation.67812817 2

Metzger WJ, Zavala D, Richerson HB, Mosely P, Iwamota P, Monick M, Sjoerdsma K, & Hunninghake GW (1987) Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs

Similarly, NAD + levels appear reduced in preclinical models of age-associated diseases, including ataxia-telangiectasia (A-T), mitochondrial myopathies, and Alzheimers disease (AD), and disease-matched clinical samples 114,242,243,244,245,246

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