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Hantute-Ghesquier A, Haustrate A, Prevarskaya N

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships

This combination is particularly concerning given that cannabis plus alcohol is one of the most frequently detected drug combinations found in car accidents

In animal models, LR3 IGF-1 was approximately 2.5-fold more potent than native IGF-1 in promoting growth, with just 44 mcg/day of LR3 producing effects equivalent to 278 mcg/day of IGF-1 (Tomas et al., 1993)