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Drug Saf 26:10751092 Wilson V, Maulik SK (2018) Herb-drug interactions in neurological disorders: a critical appraisal

Activated cisplatin preferentially binds to purine bases in the nucleophilic N7 sites, where the majority of adducts occur between two guanines on the same strand, whereas ~35% of cisplatin adducts react with purines at the opposite strands, forming interstrand crosslinks (ICLs)