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Additionally, gagunin D, a highly oxygenated diterpenoid from the marine sponge Phorbas sp., was also found to exhibit anti-melanogenic properties by downregulating the expression of proteins associated with melanosome transfer, including Rab27A, MLPH and myosin Va (133)

PC significantly reduced PF markers, including hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast-specific protein-1 (S100A4), and -SMA, while increasing E-cadherin and podoplanin expression

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The above conclusions all indicate that GPx4 plays a protective role in the development of renal fibrosis