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However, their clinical applications face several significant challenges

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158 More severe mutations such as frameshift and nonsense mutations have not been found, indicating that some residual activity is required for survival

The fact that BPC 157 can inhibit the mRNA expression of inflammatory mediators (iNOS, IL-6, IFN, and TNF-) as well as increase protein expression of HSP70, HSP90 and promote the expression of antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [37] indicate that this peptide interacts with several molecular pathways [5,25,29,31,32,33,34,35,36,37]

Individual response varies significantly

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