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10.1007/s13346-014-0199-6 69 GuglielmoA.SabraA.ElberyM.CerveiraM

Statements Author contributions YK: Supervision, Writing original draft, Conceptualization

[DOI] [PubMed] [Google Scholar] 124.Keith B., Johnson R.S., Simon M.C

J Clin Investig 122:28842897 Turchinovich A, Weiz L, Langheinz A, Burwinkel B (2011) Characterization of extracellular circulating microRNA

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This review examines the molecular mechanisms underlying ASM-associated oxidative stress in clinical, non-kindled/kindled preclinical, as well as non-epilepsy models, and highlights evidence demonstrating the ability of ascorbic acid to attenuate ROS accumulation, enhance endogenous antioxidant defenses, and modulate redox-sensitive signaling pathways implicated in epileptogenesis and ASM-induced toxicity