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For instance, the transcription factor hypoxia inducible factor-1 alpha (HIF-1) is induced in response to oxidative stress, further assisting metabolic reprogramming of cancer cells and promoting tumorigenesis

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Redox-responsive nanohydrogels, incorporating disulfide or thioketal linkages, degrade selectively in these redox environments, releasing encapsulated agents or radiosensitizers precisely where oxidative imbalance is highest [207, 208]

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