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In this model, 0.15 mg/kg BID was defined as the minimal efficacious dose, corresponding to ALG-055009 plasma C max of 82.5 ng/mL, AUC 0-24 of 515 ngh/mL and C min of 2.01 ng/mL

S2CID 32950492

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In addition, relatively small negative -potential values of TLH NP in serum might be beneficial for enhanced thrombus or activated platelet targeting 48 , although in-depth studies remain to be conducted to address mechanisms underlying the desirable targeting efficiency of TLH NP

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