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However, it is necessary to conduct further animal-based studies to corroborate these results and ensure their efficacy and safety profile for future human applications

Special therapeutic interventions are necessary to cope with these alterations because they are frequently impaired by the bloodbrain barrier, which denies drugs access to the brain

It is worth noting that UK and European medicines regulators (MHRA and EMA) continue to monitor reports of neuropsychiatric events with GLP-1 receptor agonists through their pharmacovigilance systems, but no causal association has been established at this time

doi: 10.1038/s41598-021-88438-7 117

Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, Halpern S, Crowe T, Blankenship JC, Kerensky R

Plant Cell Tissue Organ Culture (PCTOC) 146(1):97105