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Single voxel 1H-MRS spectroscopic data were acquired using point resolved spectroscopy sequence, receiving 1,024 samples with 2,000 Hz spectral bandwidth, 2,000 msec TR, 35 msec TE, 128 averages combined with excitation water suppression technique (scanning time, ~5 min)

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Although the exact mechanism of how coffee enemas cause proctocolitis is not known, it is suspected that the proctocolitis is caused by the chemicals in coffee enemas, as coffee is a complex mixture of chemical compounds that contain more than just caffeine

doi: 10.1210/jc.2002-021983 111 BelobrajdicDPFrystykJJeyaratnaganthanNEspelundUFlyvbjergACliftonPMet al