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Unlike the vancomycin halogenase VhaA for which a hexapeptidic intermediate was identified as the substrate, the teicoplanin halogenase Tcp21 demonstrated activity only for carrier protein thioesterified L-tyrosine

Xu Y, Zhang H, Sun Q, Geng R, Yuan F, Liu B

Pseudomonas aeruginosa exemplifies an organism that has evolved unusually robust, multi-layered defensesdeploying periplasmic surveillance and export (CopRSPcoBA), cytoplasmic sensing and efflux (CueR-regulated CopA/CzcR regulated CzcCBA system), and an additional small-molecule strategy in which copper is neutralized by sequestration into the organometallic complex fluopsin C

HBV is a member of the Hepadnaviridae family and is characterized by its partially double-stranded DNA structure

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