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Current research findings demonstrate that glycogen storage in aged astrocytes shows no significant difference compared to that in young astrocytes, and they maintain the capability to normally supply lactate to neuronal axons (Bastian et al

This shift can escalate cell susceptibility to apoptosis, and the tumor suppressor p53 can trigger ferroptosis, influencing tumor cell death and lifespan in preclinical models (113)

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Experimentally generated polynucleotides that exhibit the desired property can be recovered from the cell and, if further improvement is desired, the reassembly (optionally in combination with other directed evolution methods described herein) and screening, can be repeated